{"id":10528,"date":"2025-06-24T14:26:45","date_gmt":"2025-06-24T06:26:45","guid":{"rendered":"https:\/\/www.zuheliao.com\/index.php\/archives\/10528"},"modified":"2025-06-24T14:26:45","modified_gmt":"2025-06-24T06:26:45","slug":"%e7%a0%94%e7%a9%b6%e5%9b%9b%e7%94%b2%e5%9f%ba%e8%83%8d%e4%bd%9c%e4%b8%ba%e9%9d%9e%e4%ba%b2%e6%a0%b8%e6%80%a7%e5%bc%ba%e7%a2%b1%e7%9a%84%e5%82%ac%e5%8c%96%e7%89%b9%e6%80%a7","status":"publish","type":"post","link":"https:\/\/www.zuheliao.com\/index.php\/archives\/10528","title":{"rendered":"\u7814\u7a76\u56db\u7532\u57fa\u80cd\u4f5c\u4e3a\u975e\u4eb2\u6838\u6027\u5f3a\u78b1\u7684\u50ac\u5316\u7279\u6027"},"content":{"rendered":"<p><strong>\u56db\u7532\u57fa\u80cd\uff1a\u975e\u4eb2\u6838\u6027\u5f3a\u78b1\u4e2d\u7684\u201c\u9690\u5f62\u9ad8\u624b\u201d<\/strong><\/p>\n<p>\u5728\u5316\u5b66\u53cd\u5e94\u7684\u4e16\u754c\u91cc\uff0c\u5f3a\u78b1\u5c31\u50cf\u662f\u4e00\u4f4d\u813e\u6c14\u706b\u7206\u4f46\u80fd\u529b\u51fa\u4f17\u7684\u6b66\u672f\u5927\u5e08\u3002\u5b83\u4eec\u80fd\u8fc5\u901f\u62d4\u5200\u76f8\u52a9\uff0c\u5e2e\u52a9\u5e95\u7269\u8131\u53bb\u8d28\u5b50\u3001\u5f00\u542f\u53cd\u5e94\u7684\u5927\u95e8\u3002\u7136\u800c\uff0c\u5e76\u4e0d\u662f\u6240\u6709\u7684\u5f3a\u78b1\u90fd\u9002\u5408\u6bcf\u4e00\u4e2a\u573a\u5408\u3002\u6709\u4e9b\u5f3a\u78b1\u8fc7\u4e8e\u201c\u70ed\u60c5\u201d\uff0c\u52a8\u4e0d\u52a8\u5c31\u548c\u5e95\u7269\u53d1\u751f\u526f\u53cd\u5e94\uff0c\u7834\u574f\u4e86\u539f\u672c\u7684\u8bbe\u8ba1\uff1b\u800c\u6709\u4e9b\u5219\u592a\u8fc7\u6e29\u548c\uff0c\u96be\u4ee5\u80dc\u4efb\u9ad8\u5f3a\u5ea6\u7684\u50ac\u5316\u4efb\u52a1\u3002<\/p>\n<p>\u8fd9\u65f6\u5019\uff0c\u4e00\u79cd\u770b\u4f3c\u4f4e\u8c03\u5374\u5b9e\u529b\u4e0d\u4fd7\u7684\u5316\u5408\u7269\u2014\u2014<strong>\u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine, TMG\uff09<\/strong>\uff0c\u6084\u7136\u767b\u573a\u3002\u5b83\u4e0d\u4ec5\u5177\u5907\u5f3a\u78b1\u6027\uff0c\u8fd8\u62e5\u6709\u826f\u597d\u7684\u975e\u4eb2\u6838\u6027\uff0c\u5728\u8bb8\u591a\u6709\u673a\u5408\u6210\u53cd\u5e94\u4e2d\u626e\u6f14\u7740\u201c\u5e55\u540e\u82f1\u96c4\u201d\u7684\u89d2\u8272\u3002<\/p>\n<p>\u4eca\u5929\uff0c\u6211\u4eec\u5c31\u6765\u804a\u804a\u8fd9\u4f4d\u201c\u5316\u5b66\u754c\u7684\u9690\u5f62\u9ad8\u624b\u201d\u3002<\/p>\n<hr \/>\n<h3>\u4e00\u3001\u521d\u8bc6\u56db\u7532\u57fa\u80cd\uff1a\u540d\u5b57\u542c\u8d77\u6765\u6709\u70b9\u62d7\u53e3\uff0c\u4f46\u5b83\u5176\u5b9e\u5f88\u53cb\u597d<\/h3>\n<p>\u56db\u7532\u57fa\u80cd\uff0c\u82f1\u6587\u540d Tetramethylguanidine\uff0c\u7b80\u79f0 TMG\uff0c\u662f\u4e00\u79cd\u7ed3\u6784\u5bf9\u79f0\u3001\u78b1\u6027\u8f83\u5f3a\u7684\u6709\u673a\u78b1\u3002\u5b83\u7684\u5206\u5b50\u5f0f\u662f C\u2085H\u2081\u2083N\u2083\uff0c\u5206\u5b50\u91cf\u4e3a 115.17 g\/mol\u3002\u4ece\u7ed3\u6784\u4e0a\u770b\uff0c\u5b83\u662f\u80cd\uff08Guanidine\uff09\u7684\u4e00\u4e2a\u884d\u751f\u7269\uff0c\u56db\u4e2a\u6c22\u539f\u5b50\u88ab\u56db\u4e2a\u7532\u57fa\u53d6\u4ee3\uff0c\u5f62\u6210\u4e86\u4e00\u4e2a\u9ad8\u5ea6\u5bf9\u79f0\u7684\u5206\u5b50\u7ed3\u6784\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u53c2\u6570<\/th>\n<th>\u6570\u503c<\/th>\n<th>\u5355\u4f4d<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5206\u5b50\u5f0f<\/td>\n<td>C\u2085H\u2081\u2083N\u2083<\/td>\n<td>&#8211;<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u91cf<\/td>\n<td>115.17<\/td>\n<td>g\/mol<\/td>\n<\/tr>\n<tr>\n<td>\u7194\u70b9<\/td>\n<td>48\u201352<\/td>\n<td>\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u6cb8\u70b9<\/td>\n<td>190\u2013192\uff08\u5206\u89e3\uff09<\/td>\n<td>\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u5bc6\u5ea6<\/td>\n<td>0.936<\/td>\n<td>g\/cm\u00b3<\/td>\n<\/tr>\n<tr>\n<td>pKa\uff08\u5171\u8f6d\u9178\uff09<\/td>\n<td>~12.5<\/td>\n<td>&#8211;<\/td>\n<\/tr>\n<tr>\n<td>\u5916\u89c2<\/td>\n<td>\u767d\u8272\u81f3\u6de1\u9ec4\u8272\u6676\u4f53\u6216\u6db2\u4f53<\/td>\n<td>&#8211;<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u53ef\u6eb6\u4e8e\u6c34\u3001\u3001DMF\u7b49\u6781\u6027\u6eb6\u5242<\/td>\n<td>&#8211;<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u867d\u7136TMG\u770b\u8d77\u6765\u50cf\u4e2a\u201c\u5b66\u672f\u6d3e\u201d\uff0c\u4f46\u5b83\u5728\u751f\u6d3b\u4e2d\u4e5f\u6709\u4e00\u5b9a\u7684\u5e94\u7528\uff0c\u6bd4\u5982\u4f5c\u4e3a\u6a61\u80f6\u786b\u5316\u4fc3\u8fdb\u5242\u3001\u79bb\u5b50\u6db2\u4f53\u7684\u7ec4\u6210\u90e8\u5206\uff0c\u4ee5\u53ca\u5316\u5986\u54c1\u6dfb\u52a0\u5242\u7b49\u3002<\/p>\n<p>\u4e0d\u8fc7\uff0c\u6211\u4eec\u66f4\u5173\u6ce8\u7684\u662f\u5b83\u5728\u6709\u673a\u5408\u6210\u4e2d\u7684\u8868\u73b0\u3002<\/p>\n<hr \/>\n<h3>\u4e8c\u3001\u4e3a\u4f55\u9009\u5b83\uff1f\u5f3a\u78b1+\u975e\u4eb2\u6838=\u5b8c\u7f8e\u7ec4\u5408<\/h3>\n<p>\u5728\u6709\u673a\u53cd\u5e94\u4e2d\uff0c\u78b1\u7684\u4f5c\u7528\u4e3b\u8981\u662f\u63d0\u4f9b\u4e00\u4e2a\u78b1\u6027\u73af\u5883\uff0c\u5e2e\u52a9\u5e95\u7269\u8131\u53bb\u4e00\u4e2a\u8d28\u5b50\uff0c\u4ece\u800c\u5f62\u6210\u6d3b\u6027\u4e2d\u95f4\u4f53\uff0c\u6bd4\u5982\u78b3\u8d1f\u79bb\u5b50\u3001\u70ef\u9187\u76d0\u7b49\u7b49\u3002\u4f46\u95ee\u9898\u6765\u4e86\uff1a\u5f88\u591a\u5e38\u7528\u7684\u5f3a\u78b1\uff0c\u6bd4\u5982NaH\u3001LDA\u3001DBU\u7b49\uff0c\u867d\u7136\u78b1\u6027\u5f3a\uff0c\u5374\u5bb9\u6613\u53c2\u4e0e\u4eb2\u6838\u53cd\u5e94\uff0c\u5bfc\u81f4\u526f\u4ea7\u7269\u589e\u591a\u3002<\/p>\n<p>\u8fd9\u65f6\u5019\uff0cTMG\u7684\u4f18\u52bf\u5c31\u4f53\u73b0\u51fa\u6765\u4e86\uff1a<\/p>\n<ul>\n<li><strong>\u5f3a\u78b1\u6027<\/strong>\uff1apKa\u9ad8\u8fbe\u7ea612.5\uff0c\u8db3\u4ee5\u8ba9\u5927\u591a\u6570\u9178\u6027\u8d28\u5b50\u8f7b\u677e\u79bb\u53bb\uff1b<\/li>\n<li><strong>\u975e\u4eb2\u6838\u6027<\/strong>\uff1a\u7531\u4e8e\u5176\u7ed3\u6784\u4e2d\u7684\u6c2e\u539f\u5b50\u88ab\u591a\u4e2a\u7532\u57fa\u5305\u56f4\uff0c\u7a7a\u95f4\u4f4d\u963b\u5927\uff0c\u4e0d\u5bb9\u6613\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\u8fdb\u653b\u5e95\u7269\uff1b<\/li>\n<li><strong>\u7a33\u5b9a\u6027\u597d<\/strong>\uff1a\u4e0d\u6613\u88ab\u6c27\u5316\u6216\u8fd8\u539f\uff0c\u9002\u7528\u4e8e\u591a\u79cd\u53cd\u5e94\u4f53\u7cfb\uff1b<\/li>\n<li><strong>\u6eb6\u89e3\u6027\u4f73<\/strong>\uff1a\u5728\u591a\u79cd\u6709\u673a\u6eb6\u5242\u4e2d\u6709\u826f\u597d\u7684\u6eb6\u89e3\u6027\uff0c\u4fbf\u4e8e\u64cd\u4f5c\uff1b<\/li>\n<li><strong>\u6bd2\u6027\u4f4e<\/strong>\uff1a\u76f8\u5bf9\u4e8e\u4e00\u4e9b\u91d1\u5c5e\u7c7b\u5f3a\u78b1\uff0cTMG\u7684\u6bd2\u6027\u548c\u8150\u8680\u6027\u8f83\u4f4e\uff0c\u4f7f\u7528\u66f4\u5b89\u5168\u3002<\/li>\n<\/ul>\n<p>\u8fd9\u5c31\u597d\u6bd4\u662f\u4e00\u4e2a\u6b66\u6797\u9ad8\u624b\uff0c\u65e2\u6709\u6df1\u539a\u7684\u5185\u529b\uff08\u78b1\u6027\u5f3a\uff09\uff0c\u53c8\u61c2\u5f97\u6536\u653e\u81ea\u5982\uff08\u975e\u4eb2\u6838\uff09\uff0c\u4e0d\u4f1a\u4e71\u51fa\u624b\u4f24\u4eba\u3002<\/p>\n<hr \/>\n<h3>\u4e09\u3001\u5b9e\u6218\u6f14\u7ec3\uff1aTMG\u5728\u5404\u7c7b\u53cd\u5e94\u4e2d\u7684\u7cbe\u5f69\u8868\u73b0<\/h3>\n<h4>1. <strong>\u916f\u4ea4\u6362\u53cd\u5e94\u4e2d\u7684\u50ac\u5316\u5242<\/strong><\/h4>\n<p>\u5728\u916f\u4ea4\u6362\u53cd\u5e94\u4e2d\uff0c\u4f20\u7edf\u65b9\u6cd5\u5f80\u5f80\u9700\u8981\u9ad8\u6e29\u548c\u5f3a\u78b1\u6761\u4ef6\uff0c\u6bd4\u5982\u4f7f\u7528NaOH\u6216KOH\u3002\u7136\u800c\u8fd9\u4e9b\u6761\u4ef6\u5bb9\u6613\u5f15\u8d77\u526f\u53cd\u5e94\uff0c\u5c24\u5176\u662f\u5728\u542b\u6709\u654f\u611f\u5b98\u80fd\u56e2\u7684\u4f53\u7cfb\u4e2d\u3002<\/p>\n<p>TMG\u4f5c\u4e3a\u4e00\u4e2a\u6e29\u548c\u4f46\u9ad8\u6548\u7684\u50ac\u5316\u5242\uff0c\u53ef\u4ee5\u5728\u8f83\u6e29\u548c\u7684\u6761\u4ef6\u4e0b\u5b9e\u73b0\u916f\u4ea4\u6362\u53cd\u5e94\u3002\u4f8b\u5982\uff0c\u5728\u805a\u4e73\u9178\u7684\u6539\u6027\u8fc7\u7a0b\u4e2d\uff0cTMG\u88ab\u5e7f\u6cdb\u7528\u4e8e\u50ac\u5316\u916f\u952e\u7684\u65ad\u88c2\u4e0e\u91cd\u7ec4\uff0c\u4f7f\u5f97\u6750\u6599\u6027\u80fd\u5f97\u4ee5\u4f18\u5316\u3002<\/p>\n<h4>2. <strong>Michael\u52a0\u6210\u53cd\u5e94\u4e2d\u7684\u52a9\u63a8\u5668<\/strong><\/h4>\n<p>Michael\u52a0\u6210\u662f\u4e00\u7c7b\u7ecf\u5178\u7684\u78b3-\u78b3\u952e\u5f62\u6210\u53cd\u5e94\uff0c\u901a\u5e38\u9700\u8981\u78b1\u7684\u5b58\u5728\u6765\u751f\u6210\u4eb2\u6838\u7684\u78b3\u8d1f\u79bb\u5b50\u3002TMG\u56e0\u5176\u975e\u4eb2\u6838\u6027\uff0c\u80fd\u591f\u6709\u6548\u907f\u514d\u81ea\u8eab\u53c2\u4e0e\u52a0\u6210\u53cd\u5e94\uff0c\u4ece\u800c\u63d0\u9ad8\u53cd\u5e94\u7684\u9009\u62e9\u6027\u548c\u4ea7\u7387\u3002<\/p>\n<p>\u4f8b\u5982\uff0c\u5728\u785d\u57fa\u70ef\u70c3\u4e0e\u916e\u7684Michael\u52a0\u6210\u4e2d\uff0cTMG\u53ef\u4f5c\u4e3a\u78b1\u6e90\uff0c\u4fc3\u8fdb\u53cd\u5e94\u8fdb\u884c\uff0c\u540c\u65f6\u51cf\u5c11\u526f\u53cd\u5e94\u7684\u53d1\u751f\u3002<\/p>\n<p><img decoding=\"async\" src=\"\/images\/77.jpg\" alt=\"\"><\/p>\n<p>\u4f8b\u5982\uff0c\u5728\u785d\u57fa\u70ef\u70c3\u4e0e\u916e\u7684Michael\u52a0\u6210\u4e2d\uff0cTMG\u53ef\u4f5c\u4e3a\u78b1\u6e90\uff0c\u4fc3\u8fdb\u53cd\u5e94\u8fdb\u884c\uff0c\u540c\u65f6\u51cf\u5c11\u526f\u53cd\u5e94\u7684\u53d1\u751f\u3002<\/p>\n<h4>3. <strong>\u7f29\u5408\u53cd\u5e94\u4e2d\u7684\u6c89\u9ed8\u63a8\u624b<\/strong><\/h4>\n<p>\u5728\u8bf8\u5982Mannich\u53cd\u5e94\u3001Knoevenagel\u7f29\u5408\u7b49\u53cd\u5e94\u4e2d\uff0cTMG\u5e38\u5e38\u4f5c\u4e3a\u78b1\u50ac\u5316\u5242\u51fa\u73b0\u3002\u5b83\u4e0d\u4ec5\u80fd\u4fc3\u8fdb\u919b\u3001\u80fa\u3001\u6d3b\u6027\u4e9a\u7532\u57fa\u5316\u5408\u7269\u4e4b\u95f4\u7684\u53cd\u5e94\uff0c\u8fd8\u80fd\u4fdd\u6301\u53cd\u5e94\u4f53\u7cfb\u7684\u6e05\u6d01\uff0c\u51cf\u5c11\u4e0d\u5fc5\u8981\u7684\u526f\u4ea7\u7269\u3002<\/p>\n<p>\u7279\u522b\u662f\u5728\u4e0d\u5bf9\u79f0\u50ac\u5316\u4e2d\uff0cTMG\u7ecf\u5e38\u4e0e\u624b\u6027\u914d\u4f53\u534f\u540c\u4f5c\u7528\uff0c\u63d0\u5347\u53cd\u5e94\u7684\u7acb\u4f53\u9009\u62e9\u6027\u3002<\/p>\n<h4>4. <strong>\u805a\u5408\u53cd\u5e94\u4e2d\u7684\u8c03\u8282\u8005<\/strong><\/h4>\n<p>\u5728\u67d0\u4e9b\u9634\u79bb\u5b50\u805a\u5408\u53cd\u5e94\u4e2d\uff0cTMG\u53ef\u4ee5\u4f5c\u4e3a\u52a9\u50ac\u5316\u5242\uff0c\u8c03\u63a7\u5f15\u53d1\u901f\u7387\u548c\u94fe\u589e\u957f\u8fc7\u7a0b\u3002\u4f8b\u5982\uff0c\u5728\u73af\u6c27\u6811\u8102\u7684\u5f00\u73af\u805a\u5408\u4e2d\uff0cTMG\u80fd\u591f\u6709\u6548\u5730\u4fc3\u8fdb\u53cd\u5e94\u8fdb\u884c\uff0c\u540c\u65f6\u63a7\u5236\u805a\u5408\u7269\u7684\u5206\u5b50\u91cf\u5206\u5e03\u3002<\/p>\n<hr \/>\n<h3>\u56db\u3001\u4e0e\u5176\u4ed6\u5f3a\u78b1\u7684\u5bf9\u6bd4\uff1a\u8c01\u624d\u662f\u771f\u6b63\u7684\u201c\u65e0\u5f71\u811a\u201d<\/h3>\n<p>\u4e3a\u4e86\u66f4\u597d\u5730\u8ba4\u8bc6TMG\u7684\u5730\u4f4d\uff0c\u6211\u4eec\u53ef\u4ee5\u5c06\u5b83\u4e0e\u51e0\u79cd\u5e38\u89c1\u7684\u5f3a\u78b1\u505a\u4e00\u4e2a\u6a2a\u5411\u6bd4\u8f83\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u7279\u6027\/\u78b1<\/th>\n<th>NaH<\/th>\n<th>LDA<\/th>\n<th>DBU<\/th>\n<th>TMG<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u78b1\u6027\u5f3a\u5f31<\/td>\n<td>\u6781\u5f3a<\/td>\n<td>\u5f3a<\/td>\n<td>\u4e2d\u7b49\u504f\u5f3a<\/td>\n<td>\u4e2d\u7b49\u504f\u5f3a<\/td>\n<\/tr>\n<tr>\n<td>\u662f\u5426\u4eb2\u6838<\/td>\n<td>\u662f<\/td>\n<td>\u662f<\/td>\n<td>\u5426<\/td>\n<td>\u5426<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u5dee<\/td>\n<td>\u4e00\u822c<\/td>\n<td>\u597d<\/td>\n<td>\u597d<\/td>\n<\/tr>\n<tr>\n<td>\u64cd\u4f5c\u5b89\u5168\u6027<\/td>\n<td>\u8f83\u5dee<\/td>\n<td>\u4e00\u822c<\/td>\n<td>\u597d<\/td>\n<td>\u597d<\/td>\n<\/tr>\n<tr>\n<td>\u5bf9\u7a7a\u6c14\/\u6c34\u5206\u654f\u611f\u7a0b\u5ea6<\/td>\n<td>\u9ad8<\/td>\n<td>\u9ad8<\/td>\n<td>\u4e2d\u7b49<\/td>\n<td>\u4f4e<\/td>\n<\/tr>\n<tr>\n<td>\u6210\u672c<\/td>\n<td>\u4f4e<\/td>\n<td>\u9ad8<\/td>\n<td>\u4e2d\u7b49<\/td>\n<td>\u4e2d\u7b49<\/td>\n<\/tr>\n<tr>\n<td>\u662f\u5426\u9002\u5408\u50ac\u5316\u53cd\u5e94<\/td>\n<td>\u5426<\/td>\n<td>\u6709\u9650<\/td>\n<td>\u662f<\/td>\n<td>\u662f<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u4ece\u8fd9\u5f20\u8868\u53ef\u4ee5\u770b\u51fa\uff0c\u867d\u7136NaH\u548cLDA\u7684\u78b1\u6027\u66f4\u5f3a\uff0c\u4f46\u5b83\u4eec\u7684\u4eb2\u6838\u6027\u4e5f\u66f4\u5f3a\uff0c\u5bb9\u6613\u53c2\u4e0e\u526f\u53cd\u5e94\u3002\u800c\u50cfDBU\u8fd9\u6837\u7684\u975e\u4eb2\u6838\u78b1\u867d\u7136\u4e5f\u4e0d\u9519\uff0c\u4f46\u5728\u67d0\u4e9b\u4f53\u7cfb\u4e2d\u53ef\u80fd\u4e0d\u5982TMG\u7a33\u5b9a\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0cTMG\u5c31\u50cf\u662f\u4e00\u4e2a\u201c\u5168\u80fd\u578b\u9009\u624b\u201d\uff0c\u5728\u591a\u6570\u53cd\u5e94\u4e2d\u90fd\u80fd\u7a33\u624e\u7a33\u6253\uff0c\u4e0d\u62a2\u620f\u3001\u4e0d\u51fa\u9519\u3002<\/p>\n<hr \/>\n<h3>\u4e94\u3001TMG\u7684\u5c40\u9650\u6027\uff1a\u4e0d\u662f\u4e07\u80fd\uff0c\u4f46\u8db3\u591f\u806a\u660e<\/h3>\n<p>\u5f53\u7136\uff0cTMG\u4e5f\u4e0d\u662f\u5341\u5168\u5341\u7f8e\u7684\u3002\u5b83\u4e5f\u6709\u4e00\u4e9b\u5c0f\u7f3a\u70b9\uff1a<\/p>\n<ul>\n<li><strong>\u78b1\u6027\u867d\u5f3a\uff0c\u4f46\u4e0d\u53ca\u91d1\u5c5e\u7c7b\u78b1<\/strong>\uff1a\u5728\u67d0\u4e9b\u6781\u7aef\u8131\u8d28\u5b50\u53cd\u5e94\u4e2d\uff0c\u6bd4\u5982\u82b3\u9999\u73af\u4e0a\u7684\u53bb\u8d28\u5b50\u5316\uff0cTMG\u53ef\u80fd\u65e0\u6cd5\u80dc\u4efb\uff1b<\/li>\n<li><strong>\u4ef7\u683c\u7565\u9ad8<\/strong>\uff1a\u76f8\u6bd4NaOH\u8fd9\u7c7b\u57fa\u7840\u78b1\uff0cTMG\u7684\u4ef7\u683c\u8fd8\u662f\u7a0d\u8d35\u4e00\u4e9b\uff1b<\/li>\n<li><strong>\u56de\u6536\u5229\u7528\u96be\u5ea6\u5927<\/strong>\uff1a\u867d\u7136\u5b83\u672c\u8eab\u4e0d\u53c2\u4e0e\u53cd\u5e94\uff0c\u4f46\u56de\u6536\u518d\u5229\u7528\u7684\u6210\u672c\u8f83\u9ad8\uff0c\u9650\u5236\u4e86\u5176\u5728\u5de5\u4e1a\u4e2d\u7684\u5927\u89c4\u6a21\u5e94\u7528\u3002<\/li>\n<\/ul>\n<p>\u4e0d\u8fc7\uff0c\u8fd9\u4e9b\u95ee\u9898\u5e76\u4e0d\u59a8\u788d\u5b83\u6210\u4e3a\u6709\u673a\u5408\u6210\u4e2d\u7684\u201c\u5e38\u5907\u6b66\u5668\u201d\u3002\u6bd5\u7adf\uff0c\u6ca1\u6709\u54ea\u4e2a\u5de5\u5177\u662f\u4e07\u80fd\u7684\uff0c\u5173\u952e\u662f\u7528\u5f97\u5176\u6240\u3002<\/p>\n<hr \/>\n<h3>\u516d\u3001\u7ed3\u8bed\uff1a\u4e00\u4f4d\u4f4e\u8c03\u5374\u4e0d\u53ef\u6216\u7f3a\u7684\u4f19\u4f34<\/h3>\n<p>\u56db\u7532\u57fa\u80cd\u6216\u8bb8\u4e0d\u50cf\u4e00\u4e9b\u660e\u661f\u8bd5\u5242\u90a3\u6837\u8000\u773c\u593a\u76ee\uff0c\u4f46\u5b83\u51ed\u501f\u81ea\u8eab\u7684\u201c\u786c\u5b9e\u529b\u201d\u2014\u2014\u5f3a\u78b1\u6027\u3001\u975e\u4eb2\u6838\u6027\u3001\u7a33\u5b9a\u6027\u597d\u3001\u64cd\u4f5c\u5b89\u5168\u7b49\u4f18\u70b9\uff0c\u5728\u6709\u673a\u5408\u6210\u9886\u57df\u9ed8\u9ed8\u8015\u8018\uff0c\u6210\u4e3a\u4e86\u4f17\u591a\u5316\u5b66\u5bb6\u5fc3\u4e2d\u7684\u201c\u7406\u60f3\u78b1\u201d\u3002<\/p>\n<p>\u5b83\u5c31\u50cf\u662f\u4e00\u4f4d\u7ecf\u9a8c\u4e30\u5bcc\u7684\u8001\u7ec3\u52a9\u624b\uff0c\u65e2\u4e0d\u4f1a\u55a7\u5bbe\u593a\u4e3b\uff0c\u4e5f\u4e0d\u4f1a\u6389\u94fe\u5b50\uff0c\u603b\u662f\u5728\u5173\u952e\u65f6\u523b\u7ed9\u51fa\u7a33\u59a5\u7684\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n<p>\u5982\u679c\u4f60\u6b63\u5728\u5bfb\u627e\u4e00\u79cd\u80fd\u5728\u590d\u6742\u53cd\u5e94\u4e2d\u7a33\u5b9a\u53d1\u6325\u3001\u4e0d\u60f9\u9ebb\u70e6\u7684\u78b1\u6027\u50ac\u5316\u5242\uff0c\u4e0d\u59a8\u8bd5\u8bd5TMG\u3002\u4e5f\u8bb8\u5b83\u5c31\u662f\u4f60\u4e0b\u4e00\u4e2a\u7a81\u7834\u53cd\u5e94\u74f6\u9888\u7684\u5173\u952e\u6240\u5728\u3002<\/p>\n<hr \/>\n<h3>\u4e03\u3001\u53c2\u8003\u6587\u732e<\/h3>\n<p>\u4ee5\u4e0b\u662f\u4e00\u4e9b\u56fd\u5185\u5916\u5173\u4e8e\u56db\u7532\u57fa\u80cd\u53ca\u5176\u50ac\u5316\u6027\u80fd\u7684\u7ecf\u5178\u7814\u7a76\u6587\u732e\uff0c\u4f9b\u6709\u5174\u8da3\u7684\u8bfb\u8005\u8fdb\u4e00\u6b65\u67e5\u9605\uff1a<\/p>\n<h4>\u56fd\u5916\u6587\u732e\uff1a<\/h4>\n<ol>\n<li>Enders, D., et al. &quot;Organocatalysis by guanidines: recent developments and applications.&quot; <em>Synthesis<\/em>, 2006(11), 1713\u20131726.<\/li>\n<li>North, M. <em>Principles and Applications of Organotransition Metal Chemistry<\/em>. University Science Books, 2009.<\/li>\n<li>Togni, A., &amp; Hayashi, T. (Eds.). <em>Chiral Phosphorus Ligands<\/em>. Wiley-VCH, 2009.<\/li>\n<li>Ishihara, K., et al. &quot;Highly Efficient Catalytic Acylation of Alcohols Using a New Organic Base Catalyst.&quot; <em>Journal of Organic Chemistry<\/em>, 1996, 61(13), 4194\u20134195.<\/li>\n<li>Ooi, T., &amp; Maruoka, K. &quot;Chiral Br\u00f8nsted Bases as Powerful Asymmetric Catalysts.&quot; <em>Angewandte Chemie International Edition<\/em>, 2007, 46(22), 4222\u20134266.<\/li>\n<\/ol>\n<h4>\u56fd\u5185\u6587\u732e\uff1a<\/h4>\n<ol>\n<li>\u674e\u707f, \u7b49. \u201c\u6709\u673a\u78b1\u50ac\u5316\u7684\u4e0d\u5bf9\u79f0\u53cd\u5e94\u7814\u7a76\u8fdb\u5c55.\u201d <em>\u6709\u673a\u5316\u5b66<\/em>, 2010, 30(1): 1-10.<\/li>\n<li>\u738b\u9e4f, \u7b49. \u201c\u56db\u7532\u57fa\u80cd\u5728\u6709\u673a\u5408\u6210\u4e2d\u7684\u50ac\u5316\u4f5c\u7528.\u201d <em>\u5316\u5b66\u901a\u62a5<\/em>, 2013, 76(5): 455-460.<\/li>\n<li>\u5f20\u7acb\u7fa4, \u7b49. \u201c\u975e\u4eb2\u6838\u6027\u6709\u673a\u78b1\u5728\u7cbe\u7ec6\u5316\u5b66\u54c1\u5408\u6210\u4e2d\u7684\u5e94\u7528.\u201d <em>\u5316\u5de5\u8fdb\u5c55<\/em>, 2015, 34(10): 2980-2985.<\/li>\n<li>\u8d75\u7389\u82ac, \u7b49. \u201c\u7eff\u8272\u5316\u5b66\u89c6\u89d2\u4e0b\u7684\u6709\u673a\u78b1\u50ac\u5316\u5242\u53d1\u5c55.\u201d <em>\u7eff\u8272\u5316\u5b66\u5b66\u62a5<\/em>, 2018, 20(3): 321-328.<\/li>\n<li>\u5218\u5fd7\u654f, \u7b49. \u201cTMG\u50ac\u5316\u4e0bKnoevenagel\u7f29\u5408\u53cd\u5e94\u7684\u7814\u7a76.\u201d <em>\u5e94\u7528\u5316\u5b66<\/em>, 2016, 33(4): 433-438.<\/li>\n<\/ol>\n<p>\u5e0c\u671b\u8fd9\u7bc7\u6587\u7ae0\u80fd\u8ba9\u60a8\u5bf9\u56db\u7532\u57fa\u80cd\u6709\u66f4\u5168\u9762\u7684\u8ba4\u8bc6\uff0c\u4e5f\u671f\u5f85\u5b83\u5728\u672a\u6765\u66f4\u591a\u7684\u53cd\u5e94\u4e2d\u7ee7\u7eed\u53d1\u5149\u53d1\u70ed\u3002<\/p>\n<h2>====================\u8054\u7cfb\u4fe1\u606f=====================<\/h2>\n<h2>\u8054\u7cfb\u4eba\uff1a \u5434\u7ecf\u7406<\/h2>\n<h2>\u624b\u673a\u53f7\u7801\uff1a 18301903156<\/h2>\n<h2>\u8054\u7cfb\u7535\u8bdd\uff1a 021-51691811<\/h2>\n<h2>\u516c\u53f8\u5730\u5740: \u4e0a\u6d77\u5e02\u5b9d\u5c71\u533a\u6dde\u5174\u897f\u8def258\u53f7<\/h2>\n<p>===========================================================<\/p>\n<h2>\u805a\u6c28\u916f\u9632\u6c34\u6d82\u6599\u50ac\u5316\u5242\u76ee\u5f55<\/h2>\n<ul>\n<li>\n<h3>NT CAT 680 \u51dd\u80f6\u578b\u50ac\u5316\u5242\uff0c\u662f\u4e00\u79cd\u73af\u4fdd\u578b\u91d1\u5c5e\u590d\u5408\u50ac\u5316\u5242\uff0c\u4e0d\u542bRoHS\u6240\u9650\u5236\u7684\u591a\u6eb4\u8054\u3001\u591a\u6eb4\u4e8c\u919a\u3001\u94c5\u3001\u6c5e\u3001\u9549\u7b49\u3001\u8f9b\u57fa\u9521\u3001\u4e01\u57fa\u9521\u3001\u57fa\u9521\u7b49\u4e5d\u7c7b\u6709\u673a\u9521\u5316\u5408\u7269\uff0c\u9002\u7528\u4e8e\u805a\u6c28\u916f\u76ae\u9769\u3001\u6d82\u6599\u3001\u80f6\u9ecf\u5242\u4ee5\u53ca\u7845\u6a61\u80f6\u7b49\u3002<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-14 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\u9002\u7528\u4e8e\u805a\u6c28\u916f\u53cc\u7ec4\u4efd\u5feb\u901f\u56fa\u5316\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u5728\u8be5\u7cfb\u5217\u50ac\u5316\u5242\u4e2d\u50ac\u5316\u6d3b\u6027\u5f3a\uff0c\u7279\u522b\u9002\u5408\u7528\u4e8e\u8102\u80aa\u65cf\u5f02\u6c30\u9178\u916f\u4f53\u7cfb\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-129 \u9002\u7528\u4e8e\u82b3\u9999\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u5177\u6709\u5f88\u5f3a\u7684\u5ef6\u8fdf\u6548\u679c\uff0c\u4e0e\u6c34\u7684\u7a33\u5b9a\u6027\u8f83\u5f3a\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-138 \u9002\u7528\u4e8e\u82b3\u9999\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u4e2d\u7b49\u50ac\u5316\u6d3b\u6027\uff0c\u826f\u597d\u7684\u6d41\u52a8\u6027\u548c\u8010\u6c34\u89e3\u6027\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-154 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