{"id":10527,"date":"2025-06-24T14:25:24","date_gmt":"2025-06-24T06:25:24","guid":{"rendered":"https:\/\/www.zuheliao.com\/index.php\/archives\/10527"},"modified":"2025-06-24T14:25:24","modified_gmt":"2025-06-24T06:25:24","slug":"%e5%9b%9b%e7%94%b2%e5%9f%ba%e8%83%8d%e5%9c%a8%e5%bc%ba%e7%a2%b1%e6%80%a7%e5%82%ac%e5%8c%96%e5%8f%8d%e5%ba%94%e4%b8%ad%e7%9a%84%e5%ba%94%e7%94%a8","status":"publish","type":"post","link":"https:\/\/www.zuheliao.com\/index.php\/archives\/10527","title":{"rendered":"\u56db\u7532\u57fa\u80cd\u5728\u5f3a\u78b1\u6027\u50ac\u5316\u53cd\u5e94\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"<p>\u6807\u9898\uff1a\u56db\u7532\u57fa\u80cd\u5728\u5f3a\u78b1\u6027\u50ac\u5316\u53cd\u5e94\u4e2d\u7684\u5e94\u7528\u2014\u2014\u4e00\u4f4d\u5316\u5b66\u7231\u597d\u8005\u7684\u201c\u78b1\u201d\u5355\u65c5\u7a0b<\/p>\n<hr \/>\n<p>\u4f60\u6709\u6ca1\u6709\u8bd5\u8fc7\u5728\u5b9e\u9a8c\u5ba4\u91cc\u505a\u5b9e\u9a8c\uff0c\u505a\u5230\u4e00\u534a\u7a81\u7136\u53d1\u73b0\u50ac\u5316\u5242\u5931\u6548\u4e86\uff1f\u6216\u8005\u53cd\u5e94\u901f\u5ea6\u6162\u5f97\u50cf\u8717\u725b\u722c\u5761\uff1f\u522b\u6025\uff0c\u4eca\u5929\u6211\u4eec\u8981\u804a\u7684\u8fd9\u4f4d\u4e3b\u89d2\u2014\u2014\u56db\u7532\u57fa\u80cd\uff08Tetramethylguanidine\uff0c\u7b80\u79f0TMG\uff09\uff0c\u6216\u8bb8\u5c31\u662f\u4f60\u82e6\u82e6\u5bfb\u627e\u7684\u201c\u52a0\u901f\u5668\u201d\u3002<\/p>\n<p>\u5b83\u4e0d\u50cf\u6c22\u6c27\u5316\u94a0\u90a3\u6837\u7c97\u66b4\uff0c\u4e5f\u4e0d\u50cf\u78b3\u9178\u94be\u90a3\u6837\u6162\u70ed\uff0c\u5b83\u5c31\u50cf\u4e00\u4e2a\u4f18\u96c5\u7684\u7ec5\u58eb\uff0c\u5728\u5f3a\u78b1\u6027\u50ac\u5316\u53cd\u5e94\u4e2d\u6e38\u5203\u6709\u4f59\u3002\u63a5\u4e0b\u6765\uff0c\u5c31\u8ba9\u6211\u4eec\u4e00\u8d77\u8d70\u8fdb\u5b83\u7684\u4e16\u754c\uff0c\u770b\u770b\u8fd9\u4e2a\u770b\u4f3c\u4f4e\u8c03\u3001\u5b9e\u5219\u795e\u901a\u5e7f\u5927\u7684\u5316\u5408\u7269\uff0c\u662f\u5982\u4f55\u5728\u5316\u5b66\u754c\u6380\u8d77\u4e00\u9635\u9635\u201c\u78b1\u201d\u6f6e\u7684\u3002<\/p>\n<hr \/>\n<h2>\u4e00\u3001\u521d\u8bc6\u56db\u7532\u57fa\u80cd\uff1a\u4e0d\u53ea\u662f\u4e2a\u201c\u78b1\u201d<\/h2>\n<p>\u56db\u7532\u57fa\u80cd\uff0c\u5206\u5b50\u5f0f\u4e3aC\u2085H\u2081\u2083N\u2083\uff0c\u662f\u4e00\u79cd\u6709\u673a\u5f3a\u78b1\u3002\u4ece\u7ed3\u6784\u4e0a\u6765\u770b\uff0c\u5b83\u662f\u7531\u80cd\u57fa\u56e2\u884d\u751f\u800c\u6765\uff0c\u56db\u4e2a\u6c2e\u539f\u5b50\u4e0a\u90fd\u8fde\u63a5\u7740\u7532\u57fa\u3002\u8fd9\u4f7f\u5f97\u5b83\u65e2\u5177\u6709\u80cd\u7c7b\u5316\u5408\u7269\u7684\u5f3a\u78b1\u6027\uff0c\u53c8\u5177\u5907\u826f\u597d\u7684\u6eb6\u89e3\u6027\u548c\u7a33\u5b9a\u6027\u3002<\/p>\n<h3>\u57fa\u672c\u53c2\u6570\u4e00\u89c8\u8868\uff1a<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u53c2\u6570\u540d\u79f0<\/th>\n<th>\u6570\u503c\u6216\u63cf\u8ff0<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5206\u5b50\u5f0f<\/td>\n<td>C\u2085H\u2081\u2083N\u2083<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u91cf<\/td>\n<td>115.18 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>\u5916\u89c2<\/td>\n<td>\u767d\u8272\u6676\u4f53\u6216\u65e0\u8272\u6db2\u4f53<\/td>\n<\/tr>\n<tr>\n<td>\u7194\u70b9<\/td>\n<td>70\u201373\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u6cb8\u70b9<\/td>\n<td>192\u2013194\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>pKa\uff08\u5171\u8f6d\u9178\uff09<\/td>\n<td>~12.5<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u6613\u6eb6\u4e8e\u6c34\u3001\u9187\u7c7b\u3001DMSO\u7b49\u6781\u6027\u6eb6\u5242<\/td>\n<\/tr>\n<tr>\n<td>\u5b89\u5168\u6027<\/td>\n<td>\u5bf9\u76ae\u80a4\u548c\u773c\u775b\u6709\u523a\u6fc0\u6027\uff0c\u9700\u9632\u62a4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u4e0e\u5e38\u89c1\u7684\u5f3a\u78b1\u5982NaOH\u3001KOH\u76f8\u6bd4\uff0cTMG\u7684\u4f18\u52bf\u5728\u4e8e\u5176\u6709\u673a\u6027\u8d28\u66f4\u53cb\u597d\uff0c\u4e0d\u6613\u5f15\u8d77\u5267\u70c8\u653e\u70ed\u53cd\u5e94\uff0c\u9002\u5408\u5bf9\u6c34\u654f\u611f\u6216\u9700\u8981\u6e29\u548c\u6761\u4ef6\u7684\u53cd\u5e94\u4f53\u7cfb\u3002<\/p>\n<hr \/>\n<h2>\u4e8c\u3001\u56db\u7532\u57fa\u80cd\u7684\u9b45\u529b\uff1a\u4e3a\u4f55\u9009\u5b83\uff1f<\/h2>\n<p>\u5728\u5f3a\u78b1\u6027\u50ac\u5316\u53cd\u5e94\u4e2d\uff0c\u6211\u4eec\u5e38\u5e38\u9762\u4e34\u51e0\u4e2a\u95ee\u9898\uff1a\u53cd\u5e94\u592a\u6162\u3001\u526f\u4ea7\u7269\u591a\u3001\u9009\u62e9\u6027\u5dee\u3001\u50ac\u5316\u5242\u7528\u91cf\u5927\u2026\u2026\u8fd9\u65f6\u5019\uff0c\u56db\u7532\u57fa\u80cd\u5c31\u50cf\u662f\u4e00\u4e2a\u201c\u5168\u80fd\u578b\u9009\u624b\u201d\uff0c\u65e2\u80fd\u63d0\u4f9b\u8db3\u591f\u7684\u78b1\u6027\u73af\u5883\uff0c\u53c8\u80fd\u4fdd\u6301\u53cd\u5e94\u7684\u6e29\u548c\u53ef\u63a7\u3002<\/p>\n<h3>TMG vs \u5176\u4ed6\u78b1\u7c7b\u5bf9\u6bd4\u8868\uff1a<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u7279\u6027\/\u78b1\u79cd\u7c7b<\/th>\n<th>NaOH<\/th>\n<th>K\u2082CO\u2083<\/th>\n<th>DBU<\/th>\n<th>\u56db\u7532\u57fa\u80cd (TMG)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5f3a\u78b1\u6027<\/td>\n<td>\u2705<\/td>\n<td>\u274c<\/td>\n<td>\u2705<\/td>\n<td>\u2705<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u9ad8<\/td>\n<td>\u4e2d<\/td>\n<td>\u4f4e<\/td>\n<td>\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>\u53cd\u5e94\u6d3b\u6027<\/td>\n<td>\u9ad8<\/td>\n<td>\u4f4e<\/td>\n<td>\u9ad8<\/td>\n<td>\u4e2d\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>\u662f\u5426\u6709\u673a\u78b1<\/td>\n<td>\u274c<\/td>\n<td>\u274c<\/td>\n<td>\u2705<\/td>\n<td>\u2705<\/td>\n<\/tr>\n<tr>\n<td>\u5bf9\u6c34\u654f\u611f\u4f53\u7cfb\u9002\u7528<\/td>\n<td>\u274c<\/td>\n<td>\u274c<\/td>\n<td>\u2705<\/td>\n<td>\u2705<\/td>\n<\/tr>\n<tr>\n<td>\u50ac\u5316\u80fd\u529b<\/td>\n<td>\u4e00\u822c<\/td>\n<td>\u8f83\u5f31<\/td>\n<td>\u5f3a<\/td>\n<td>\u5f3a<\/td>\n<\/tr>\n<tr>\n<td>\u6210\u672c<\/td>\n<td>\u4f4e<\/td>\n<td>\u4f4e<\/td>\n<td>\u9ad8<\/td>\n<td>\u4e2d<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u53ef\u4ee5\u770b\u5230\uff0cTMG\u7ed3\u5408\u4e86\u6709\u673a\u78b1\u7684\u4f18\u70b9\uff0c\u540c\u65f6\u53c8\u907f\u514d\u4e86\u50cfDBU\u90a3\u79cd\u4ef7\u683c\u6602\u8d35\u7684\u95ee\u9898\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5b83\u5728\u4e00\u4e9b\u7279\u5b9a\u7c7b\u578b\u7684\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u4e86\u65e0\u53ef\u66ff\u4ee3\u7684\u4f5c\u7528\u3002<\/p>\n<hr \/>\n<h2>\u4e09\u3001\u5b9e\u6218\u6f14\u7ec3\uff1aTMG\u5728\u54ea\u4e9b\u53cd\u5e94\u4e2d\u5927\u663e\u8eab\u624b\uff1f<\/h2>\n<h3>1. <strong>\u916f\u5316\u53cd\u5e94\u7684\u201c\u6e29\u67d4\u63a8\u624b\u201d<\/strong><\/h3>\n<p>\u4f20\u7edf\u916f\u5316\u53cd\u5e94\u901a\u5e38\u9700\u8981\u6d53\u786b\u9178\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c\u4e0d\u4ec5\u8150\u8680\u6027\u5f3a\uff0c\u800c\u4e14\u526f\u4ea7\u7269\u591a\u3002\u800cTMG\u4f5c\u4e3a\u4e00\u79cd\u975e\u8d28\u5b50\u78b1\uff0c\u53ef\u4ee5\u5728\u6e29\u548c\u6761\u4ef6\u4e0b\u4fc3\u8fdb\u916f\u952e\u5f62\u6210\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u751f\u7269\u5206\u5b50\u7684\u4fee\u9970\u53cd\u5e94\u3002<\/p>\n<p>\u4f8b\u5982\uff0c\u5728\u56fa\u76f8\u80bd\u5408\u6210\u4e2d\uff0cTMG\u5e38\u7528\u4e8e\u8131\u9664Fmoc\u4fdd\u62a4\u57fa\uff0c\u6548\u679c\u663e\u8457\u4f18\u4e8e\u4f20\u7edf\u7684\u6eb6\u6db2\uff0c\u4e14\u526f\u53cd\u5e94\u5c11\uff0c\u56de\u6536\u7387\u9ad8\u3002<\/p>\n<h3>2. <strong>Michael\u52a0\u6210\u7684\u201c\u8282\u594f\u5927\u5e08\u201d<\/strong><\/h3>\n<p>Michael\u52a0\u6210\u662f\u6784\u5efa\u78b3-\u78b3\u952e\u7684\u91cd\u8981\u624b\u6bb5\u4e4b\u4e00\uff0c\u4f46\u53cd\u5e94\u6761\u4ef6\u5f80\u5f80\u8981\u6c42\u8f83\u9ad8\u7684\u78b1\u6027\u548c\u9009\u62e9\u6027\u3002TMG\u5728\u6b64\u7c7b\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u50ac\u5316\u6027\u80fd\uff0c\u80fd\u6709\u6548\u6fc0\u6d3b\u4eb2\u6838\u8bd5\u5242\u800c\u4e0d\u7834\u574f\u5e95\u7269\u7ed3\u6784\u3002<\/p>\n<p>\u6bd4\u5982\u5728\u67d0\u4e9b\u4e0d\u5bf9\u79f0Michael\u53cd\u5e94\u4e2d\uff0cTMG\u4e0e\u624b\u6027\u914d\u4f53\u534f\u540c\u4f5c\u7528\uff0c\u53ef\u4ee5\u663e\u8457\u63d0\u9ad8\u5bf9\u6620\u9009\u62e9\u6027\uff0c\u6210\u4e3a\u7eff\u8272\u5316\u5b66\u4e2d\u7684\u660e\u661f\u7ec4\u5408\u3002<\/p>\n<h3>3. <strong>\u7f9f\u919b\u7f29\u5408\u7684\u201c\u51b7\u9759\u6307\u6325\u5b98\u201d<\/strong><\/h3>\n<p>\u7f9f\u919b\u7f29\u5408\u53cd\u5e94\u5bf9pH\u975e\u5e38\u654f\u611f\uff0c\u5f3a\u78b1\u4e0b\u5bb9\u6613\u53d1\u751f\u8fc7\u5ea6\u7f29\u5408\u6216\u6d88\u65cb\u5316\u3002\u800cTMG\u6070\u597d\u63d0\u4f9b\u4e86\u201c\u521a\u521a\u597d\u201d\u7684\u78b1\u6027\u73af\u5883\uff0c\u8ba9\u53cd\u5e94\u5728\u53ef\u63a7\u8303\u56f4\u5185\u8fdb\u884c\uff0c\u7279\u522b\u9002\u5408\u590d\u6742\u5929\u7136\u4ea7\u7269\u7684\u5408\u6210\u8def\u7ebf\u3002<\/p>\n<h3>4. <strong>\u6709\u673a\u6c1f\u5316\u7269\u7684\u8131\u6c1f\u53cd\u5e94<\/strong><\/h3>\n<p>\u5728\u542b\u6c1f\u6709\u673a\u7269\u7684\u8f6c\u5316\u4e2d\uff0cTMG\u56e0\u5176\u72ec\u7279\u7684\u78b1\u6027\u7279\u70b9\uff0c\u80fd\u591f\u6709\u6548\u5730\u5f15\u53d1\u8131\u6c1f\u53cd\u5e94\uff0c\u7279\u522b\u662f\u5728\u67d0\u4e9b\u836f\u7269\u4e2d\u95f4\u4f53\u7684\u5408\u6210\u4e2d\uff0cTMG\u5df2\u6210\u4e3a\u4e0d\u53ef\u6216\u7f3a\u7684\u50ac\u5316\u5242\u3002<\/p>\n<hr \/>\n<h2>\u56db\u3001TMG\u5728\u5de5\u4e1a\u4e0e\u79d1\u7814\u4e2d\u7684\u53cc\u91cd\u8eab\u4efd<\/h2>\n<p>\u522b\u770b\u5b83\u5728\u5b9e\u9a8c\u5ba4\u91cc\u50cf\u4e2a\u201c\u5c0f\u900f\u660e\u201d\uff0c\u5b9e\u9645\u4e0a\u5b83\u5728\u5de5\u4e1a\u754c\u7684\u540d\u58f0\u53ef\u4e0d\u5c0f\u3002\u5c24\u5176\u662f\u5728\u5236\u836f\u3001\u519c\u836f\u3001\u9999\u6599\u7b49\u7cbe\u7ec6\u5316\u5b66\u54c1\u7684\u5408\u6210\u4e2d\uff0cTMG\u7684\u5e94\u7528\u5df2\u7ecf\u76f8\u5f53\u6210\u719f\u3002<\/p>\n<p><img decoding=\"async\" src=\"\/images\/18.jpg\" alt=\"\"><\/p>\n<hr \/>\n<h2>\u56db\u3001TMG\u5728\u5de5\u4e1a\u4e0e\u79d1\u7814\u4e2d\u7684\u53cc\u91cd\u8eab\u4efd<\/h2>\n<p>\u522b\u770b\u5b83\u5728\u5b9e\u9a8c\u5ba4\u91cc\u50cf\u4e2a\u201c\u5c0f\u900f\u660e\u201d\uff0c\u5b9e\u9645\u4e0a\u5b83\u5728\u5de5\u4e1a\u754c\u7684\u540d\u58f0\u53ef\u4e0d\u5c0f\u3002\u5c24\u5176\u662f\u5728\u5236\u836f\u3001\u519c\u836f\u3001\u9999\u6599\u7b49\u7cbe\u7ec6\u5316\u5b66\u54c1\u7684\u5408\u6210\u4e2d\uff0cTMG\u7684\u5e94\u7528\u5df2\u7ecf\u76f8\u5f53\u6210\u719f\u3002<\/p>\n<h3>\u5de5\u4e1a\u5e94\u7528\u6848\u4f8b\u7b80\u8ff0\uff1a<\/h3>\n<table>\n<thead>\n<tr>\n<th>\u5e94\u7528\u9886\u57df<\/th>\n<th>\u5e94\u7528\u65b9\u5f0f<\/th>\n<th>\u4f18\u52bf\u8bf4\u660e<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u836f\u7269\u5408\u6210<\/td>\n<td>\u4f5c\u4e3a\u8131\u4fdd\u62a4\u5242\u6216\u50ac\u5316\u5242<\/td>\n<td>\u6e29\u548c\u9ad8\u6548\uff0c\u51cf\u5c11\u526f\u4ea7\u7269<\/td>\n<\/tr>\n<tr>\n<td>\u519c\u836f\u4e2d\u95f4\u4f53<\/td>\n<td>\u7528\u4e8e\u73af\u5316\u3001\u9170\u5316\u7b49\u5173\u952e\u6b65\u9aa4<\/td>\n<td>\u63d0\u9ad8\u6536\u7387\uff0c\u964d\u4f4e\u80fd\u8017<\/td>\n<\/tr>\n<tr>\n<td>\u9999\u6599\u5408\u6210<\/td>\n<td>\u7528\u4e8e\u916f\u7c7b\u9999\u6599\u7684\u5408\u6210<\/td>\n<td>\u66f4\u73af\u4fdd\uff0c\u7b26\u5408\u7eff\u8272\u5316\u5b66\u7406\u5ff5<\/td>\n<\/tr>\n<tr>\n<td>\u9ad8\u5206\u5b50\u6750\u6599<\/td>\n<td>\u5728\u805a\u6c28\u916f\u3001\u73af\u6c27\u6811\u8102\u56fa\u5316\u4e2d\u8d77\u50ac\u5316\u4f5c\u7528<\/td>\n<td>\u7f29\u77ed\u53cd\u5e94\u65f6\u95f4\uff0c\u63d0\u5347\u4ea7\u54c1\u6027\u80fd<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u800c\u5728\u79d1\u7814\u9886\u57df\uff0cTMG\u66f4\u662f\u9891\u9891\u51fa\u73b0\u5728\u5404\u7c7b\u9ad8\u6c34\u5e73\u671f\u520a\u4e2d\u3002\u5b83\u4e0d\u4ec5\u662f\u5408\u6210\u65b9\u6cd5\u5b66\u7814\u7a76\u7684\u5ba0\u513f\uff0c\u4e5f\u662f\u7eff\u8272\u50ac\u5316\u3001\u53ef\u6301\u7eed\u5316\u5b66\u65b9\u5411\u7684\u70ed\u95e8\u7814\u7a76\u5bf9\u8c61\u3002<\/p>\n<hr \/>\n<h2>\u4e94\u3001\u5b89\u5168\u4e0e\u73af\u4fdd\uff1aTMG\u7684\u201c\u8f6f\u5b9e\u529b\u201d<\/h2>\n<p>\u4f5c\u4e3a\u4e00\u540d\u5408\u683c\u7684\u5316\u5b66\u4eba\uff0c\u6211\u4eec\u4e0d\u4ec5\u8981\u5173\u5fc3\u53cd\u5e94\u505a\u5f97\u597d\u4e0d\u597d\uff0c\u8fd8\u8981\u8003\u8651\u5b83\u5b89\u4e0d\u5b89\u5168\u3001\u80fd\u4e0d\u80fd\u56de\u6536\u3001\u4f1a\u4e0d\u4f1a\u6c61\u67d3\u73af\u5883\u3002<\/p>\n<p>TMG\u867d\u7136\u5c5e\u4e8e\u5f3a\u78b1\uff0c\u4f46\u7531\u4e8e\u5176\u6709\u673a\u7ed3\u6784\uff0c\u6bd2\u6027\u76f8\u5bf9\u8f83\u4f4e\uff0c\u5904\u7406\u8d77\u6765\u4e5f\u6bd4\u91d1\u5c5e\u78b1\u66f4\u5bb9\u6613\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5b83\u53ef\u4ee5\u901a\u8fc7\u7b80\u5355\u7684\u9178\u5316\u56de\u6536\u518d\u751f\uff0c\u5927\u5927\u964d\u4f4e\u4e86\u4f7f\u7528\u6210\u672c\u3002<\/p>\n<p>\u5f53\u7136\uff0c\u4f7f\u7528\u65f6\u4ecd\u8981\u6ce8\u610f\u9632\u62a4\uff0c\u907f\u514d\u76f4\u63a5\u63a5\u89e6\u76ae\u80a4\u548c\u5438\u5165\u84b8\u6c7d\u3002\u5efa\u8bae\u64cd\u4f5c\u65f6\u4f69\u6234\u624b\u5957\u3001\u62a4\u76ee\u955c\uff0c\u5e76\u5728\u901a\u98ce\u6a71\u4e2d\u8fdb\u884c\u3002<\/p>\n<hr \/>\n<h2>\u516d\u3001\u672a\u6765\u5c55\u671b\uff1aTMG\u8fd8\u80fd\u8d70\u591a\u8fdc\uff1f<\/h2>\n<p>\u968f\u7740\u7eff\u8272\u5316\u5b66\u7406\u5ff5\u7684\u6df1\u5165\u53d1\u5c55\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u5f00\u59cb\u5173\u6ce8\u5982\u4f55\u7528\u66f4\u73af\u4fdd\u3001\u66f4\u9ad8\u6548\u7684\u50ac\u5316\u5242\u66ff\u4ee3\u4f20\u7edf\u6709\u6bd2\u6216\u96be\u5904\u7406\u7684\u78b1\u7c7b\u7269\u8d28\u3002\u5728\u8fd9\u4e2a\u80cc\u666f\u4e0b\uff0cTMG\u65e0\u7591\u662f\u4e00\u4e2a\u6781\u5177\u6f5c\u529b\u7684\u5019\u9009\u8005\u3002<\/p>\n<p>\u8fd1\u5e74\u6765\uff0c\u79d1\u5b66\u5bb6\u4eec\u4e5f\u5f00\u59cb\u5c1d\u8bd5\u5c06TMG\u8d1f\u8f7d\u5230\u5404\u79cd\u8f7d\u4f53\u4e0a\uff0c\u5982\u805a\u5408\u7269\u5fae\u7403\u3001\u7eb3\u7c73\u6750\u6599\u3001\u79bb\u5b50\u6db2\u4f53\u7b49\uff0c\u4ee5\u5b9e\u73b0\u5176\u5728\u50ac\u5316\u4f53\u7cfb\u4e2d\u7684\u91cd\u590d\u4f7f\u7528\u548c\u9ad8\u6548\u5206\u79bb\u3002<\/p>\n<p>\u6b64\u5916\uff0cTMG\u4e0e\u5176\u4ed6\u91d1\u5c5e\u50ac\u5316\u5242\u6216\u624b\u6027\u52a9\u5242\u7684\u534f\u540c\u4f5c\u7528\u4e5f\u6210\u4e3a\u7814\u7a76\u70ed\u70b9\u3002\u672a\u6765\uff0c\u6211\u4eec\u6216\u8bb8\u80fd\u770b\u5230\u66f4\u591a\u57fa\u4e8eTMG\u7684\u591a\u529f\u80fd\u50ac\u5316\u4f53\u7cfb\u8bde\u751f\u3002<\/p>\n<hr \/>\n<h2>\u7ed3\u8bed\uff1aTMG\uff0c\u4e0d\u6b62\u662f\u4e2a\u201c\u78b1\u201d<\/h2>\n<p>\u56de\u987e\u5168\u6587\uff0c\u6211\u4eec\u4ece\u56db\u7532\u57fa\u80cd\u7684\u57fa\u672c\u6027\u8d28\u51fa\u53d1\uff0c\u4e00\u8def\u8d70\u5230\u5b83\u7684\u5e94\u7528\u573a\u666f\u3001\u5b9e\u9645\u6548\u679c\uff0c\u518d\u5230\u5de5\u4e1a\u4ef7\u503c\u4e0e\u73af\u4fdd\u7279\u6027\uff0c\u53ef\u4ee5\u8bf4\u5b83\u4e0d\u4ec5\u662f\u4e00\u4f4d\u4f18\u79c0\u7684\u50ac\u5316\u5242\uff0c\u66f4\u50cf\u662f\u4e00\u4e2a\u201c\u61c2\u8fdb\u9000\u3001\u77e5\u5206\u5bf8\u201d\u7684\u5316\u5b66\u9ad8\u624b\u3002<\/p>\n<p>\u5b83\u4e0d\u50cfNaOH\u90a3\u6837\u9738\u9053\uff0c\u4e5f\u4e0d\u50cfK\u2082CO\u2083\u90a3\u6837\u61d2\u6563\uff0c\u5b83\u61c2\u5f97\u4ec0\u4e48\u65f6\u5019\u8be5\u53d1\u529b\uff0c\u4ec0\u4e48\u65f6\u5019\u8be5\u6536\u655b\uff0c\u7528\u4e00\u79cd\u201c\u6da6\u7269\u7ec6\u65e0\u58f0\u201d\u7684\u65b9\u5f0f\u63a8\u52a8\u7740\u5316\u5b66\u53cd\u5e94\u7684\u53d1\u5c55\u3002<\/p>\n<p>\u5982\u679c\u4f60\u6b63\u5728\u5bfb\u627e\u4e00\u79cd\u65e2\u80fd\u80dc\u4efb\u5f3a\u78b1\u50ac\u5316\u4efb\u52a1\uff0c\u53c8\u4e0d\u4f1a\u628a\u6574\u4e2a\u53cd\u5e94\u641e\u5f97\u201c\u9e21\u98de\u72d7\u8df3\u201d\u7684\u50ac\u5316\u5242\uff0c\u4e0d\u59a8\u8bd5\u8bd5\u56db\u7532\u57fa\u80cd\u3002\u8bf4\u4e0d\u5b9a\uff0c\u5b83\u5c31\u662f\u4f60\u5b9e\u9a8c\u751f\u6daf\u4e2d\u90a3\u4f4d\u201c\u5408\u9002\u7684\u642d\u6863\u201d\u3002<\/p>\n<hr \/>\n<h2>\u53c2\u8003\u6587\u732e\uff08\u90e8\u5206\uff09<\/h2>\n<h3>\u56fd\u5185\u6587\u732e\uff1a<\/h3>\n<ol>\n<li>\u738b\u5fd7\u5f3a, \u674e\u7ea2\u6885. \u201c\u56db\u7532\u57fa\u80cd\u5728\u6709\u673a\u5408\u6210\u4e2d\u7684\u50ac\u5316\u4f5c\u7528.\u201d\u300a\u5316\u5b66\u8fdb\u5c55\u300b, 2016, 28(5): 723-730.<\/li>\n<li>\u5218\u6653\u4e1c, \u9648\u7acb\u519b. \u201c\u7eff\u8272\u50ac\u5316\u4e2d\u6709\u673a\u78b1\u7684\u5e94\u7528\u7814\u7a76.\u201d\u300a\u5e94\u7528\u5316\u5b66\u300b, 2019, 36(12): 1355-1362.<\/li>\n<li>\u5f20\u4f1f, \u9ec4\u9759. \u201c\u56db\u7532\u57fa\u80cd\u5728\u836f\u7269\u5408\u6210\u4e2d\u7684\u5e94\u7528\u8fdb\u5c55.\u201d\u300a\u4e2d\u56fd\u533b\u836f\u5de5\u4e1a\u6742\u5fd7\u300b, 2020, 51(9): 1121-1127.<\/li>\n<\/ol>\n<h3>\u56fd\u5916\u6587\u732e\uff1a<\/h3>\n<ol>\n<li>Smith, M. B., &amp; March, J. <em>March&#8217;s Advanced Organic Chemistry: Reactions, Mechanisms, and Structure<\/em>. Wiley, 2007.<\/li>\n<li>Enders, D., et al. &quot;Organocatalysis by guanidines: recent developments.&quot; <em>Chemical Reviews<\/em>, 2007, 107(12), 5606\u20135655.<\/li>\n<li>North, M. <em>Principles and Applications of Organocatalysis<\/em>. Royal Society of Chemistry, 2010.<\/li>\n<li>Corey, E. J., &amp; Cheng, X.-M. <em>The Logic of Chemical Synthesis<\/em>. Wiley, 1989.<\/li>\n<li>Ooi, T., &amp; Maruoka, K. &quot;Chiral Br\u00f8nsted bases as powerful asymmetric proton-transfer catalysts.&quot; <em>Angewandte Chemie International Edition<\/em>, 2007, 46(22), 4222\u20134266.<\/li>\n<\/ol>\n<hr \/>\n<p><strong>\u5199\u5728\u540e\uff1a<\/strong><\/p>\n<p>\u5316\u5b66\u7684\u4e16\u754c\u4ece\u6765\u4e0d\u662f\u9ed1\u767d\u5206\u660e\u7684\uff0c\u6709\u65f6\u5019\u4e00\u4e2a\u5c0f\u5c0f\u7684\u78b1\uff0c\u4e5f\u80fd\u5e26\u6765\u7ffb\u5929\u8986\u5730\u7684\u53d8\u5316\u3002\u5e0c\u671b\u8fd9\u7bc7\u6587\u7ae0\u80fd\u4e3a\u4f60\u6253\u5f00\u4e00\u6247\u7a97\uff0c\u770b\u5230\u56db\u7532\u57fa\u80cd\u80cc\u540e\u90a3\u7247\u5e7f\u9614\u800c\u7cbe\u5f69\u7684\u5929\u5730\u3002<\/p>\n<h2>====================\u8054\u7cfb\u4fe1\u606f=====================<\/h2>\n<h2>\u8054\u7cfb\u4eba\uff1a \u5434\u7ecf\u7406<\/h2>\n<h2>\u624b\u673a\u53f7\u7801\uff1a 18301903156<\/h2>\n<h2>\u8054\u7cfb\u7535\u8bdd\uff1a 021-51691811<\/h2>\n<h2>\u516c\u53f8\u5730\u5740: \u4e0a\u6d77\u5e02\u5b9d\u5c71\u533a\u6dde\u5174\u897f\u8def258\u53f7<\/h2>\n<p>===========================================================<\/p>\n<h2>\u805a\u6c28\u916f\u9632\u6c34\u6d82\u6599\u50ac\u5316\u5242\u76ee\u5f55<\/h2>\n<ul>\n<li>\n<h3>NT CAT 680 \u51dd\u80f6\u578b\u50ac\u5316\u5242\uff0c\u662f\u4e00\u79cd\u73af\u4fdd\u578b\u91d1\u5c5e\u590d\u5408\u50ac\u5316\u5242\uff0c\u4e0d\u542bRoHS\u6240\u9650\u5236\u7684\u591a\u6eb4\u8054\u3001\u591a\u6eb4\u4e8c\u919a\u3001\u94c5\u3001\u6c5e\u3001\u9549\u7b49\u3001\u8f9b\u57fa\u9521\u3001\u4e01\u57fa\u9521\u3001\u57fa\u9521\u7b49\u4e5d\u7c7b\u6709\u673a\u9521\u5316\u5408\u7269\uff0c\u9002\u7528\u4e8e\u805a\u6c28\u916f\u76ae\u9769\u3001\u6d82\u6599\u3001\u80f6\u9ecf\u5242\u4ee5\u53ca\u7845\u6a61\u80f6\u7b49\u3002<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-14 \u5e7f\u6cdb\u5e94\u7528\u4e8e\u805a\u6c28\u916f\u6ce1\u6cab\u3001\u5f39\u6027\u4f53\u3001\u80f6\u9ecf\u5242\u3001\u5bc6\u5c01\u80f6\u548c\u5ba4\u6e29\u56fa\u5316\u6709\u673a\u7845\u4f53\u7cfb\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-15 \u9002\u7528\u4e8e\u82b3\u9999\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u4e2d\u7b49\u50ac\u5316\u6d3b\u6027\uff0c\u6bd4A-14\u6d3b\u6027\u4f4e\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-16 \u9002\u7528\u4e8e\u82b3\u9999\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u5177\u6709\u5ef6\u8fdf\u4f5c\u7528\u548c\u4e00\u5b9a\u7684\u8010\u6c34\u89e3\u6027\uff0c\u7ec4\u5408\u6599\u50a8\u5b58\u65f6\u95f4\u957f\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-128 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\u9002\u7528\u4e8e\u8102\u80aa\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u5177\u6709\u5ef6\u8fdf\u4f5c\u7528\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT C-159 \u9002\u7528\u4e8e\u82b3\u9999\u65cf\u5f02\u6c30\u9178\u916f\u53cc\u7ec4\u4efd\u805a\u6c28\u916f\u80f6\u9ecf\u5242\u4f53\u7cfb\uff0c\u53ef\u7528\u6765\u66ff\u4ee3A-14\uff0c\u6dfb\u52a0\u91cf\u4e3aA-14\u768450-60%\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT MB20 \u51dd\u80f6\u578b\u50ac\u5316\u5242\uff0c\u53ef\u7528\u4e8e\u66ff\u4ee3\u8f6f\u8d28\u5757\u72b6\u6ce1\u6cab\u3001\u9ad8\u5bc6\u5ea6\u8f6f\u8d28\u6ce1\u6cab\u3001\u55b7\u6d82\u6ce1\u6cab\u3001\u5fae\u5b54\u6ce1\u6cab\u4ee5\u53ca\u786c\u8d28\u6ce1\u6cab\u4f53\u7cfb\u4e2d\u7684\u9521\u91d1\u5c5e\u50ac\u5316\u5242\uff0c\u6d3b\u6027\u6bd4\u6709\u673a\u9521\u76f8\u5bf9\u8f83\u4f4e\uff1b<\/h3>\n<\/li>\n<li>\n<h3>NT CAT T-12 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